![]() This medicine is available over-the-counter and does not require a prescription.įind an in-network doctor, dentist, or facility You may stop using this medicine if you no longer have symptoms. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Tell your doctor and pharmacist about all your medicines. Wash your hands after using this medicine unless your hands are part of the area being treated. Wash your hands before and after handling this medicine. Gently rub the medicine into area until evenly spread. Wash the medicine off your fingers after applying it. It is best to avoid using these products on the affected area until you are done using this medicine.Īvoid getting the medicine in the eyes, nose, or mouth. This medicine should only be used on the skin.ĭo not apply other lotions, gels, creams or cosmetics for at least 30 minutes after using this medicine. Small amounts of metabolites are also excreted in feces.Wash the area first before applying medicine.ĭo not cover the area after applying the medicine. Inactive metabolites are excreted by the kidneys, primarily as glucuronides and sulfates, but also as unconjugated products. Hydrocortisone circulates in the blood with 80% bound to transcortin and 10% to albumin. Intraocular penetration occurs and contributes to the effectiveness of hydrocortisone in anterior segment inflammatory disease. Metabolism is similar to other corticosteroids. ![]() The small amount absorbed into systemic circulation is metabolized primarily in the liver and most body tissues to hydrogenated and degraded forms such as tetrahydrocortisone and tetrahydrocortisol. Sufficient absorption may occur after topical application to the epidermis and the mucous membrances of the eyes to produce systemic effects.Īfter topical administration, hydrocortisone is metabolized primarily in the epidermis and the mucous membrances of the eyes. Hydrocortisone hardly penetrates into intraocular fluid through the cornea. ![]() Thus, in addition to the elimination of inflammation and pruritis, a normalisation of keratinisation, inhibition of excess fibroblast activity and epidermopoiesis, degradation of pathological metabolic products and inhibition of acantholysis are achieved. It may also be used for its glucocorticoid properties in other conditions for which corticosteroid therapy is indicated but drugs with fewer mineralocorticoid effects tend to be preferred for the long-term systemic therapy of auto-immune and inflammatory disease. Hydrocortisone is used, usually with a more potent mineralocorticoid, for replacement therapy in adrenocortical insufficiency. ![]() As cortisol it is the most important of the predominantly glucocorticoid steroids secreted by the adrenal cortex. Hydrocortisone is a corticosteroid with both glucocorticoid and to a lesser extent mineralocorticoid activity. Short-acting glucocorticoid that depresses formation, release, and activity of endogenous mediators of inflammation including prostaglandins, kinins, histamine, liposomal enzymes, and complement system. Pharmacotherapeutic Group: Corticosteroids.Ĭorticosteroids share anti-inflammatory, anti-pruritic and vasoconstrictive actions. In those diseases causing thinning of the cornea or sclera, perforations have been known to occur with the use of topical corticosteroids.Ĭorticosteroids may reduce resistance to and aid in the establishment of bacterial, and fungal infections and mask the clinical signs of infections, preventing recognition of ineffectiveness of the antibioticįungal infection should be suspected in patients with persistent corneal ulceration who has been or are receiving glucocorticoid for a long time, and corticosteroids therapy should be discontinued if fungal infection occurs. Topical ophthalmic corticosteroids may slow corneal wound healing. Prolonged use (more than 10 days) may result in ocular hypertension and/or steroid glaucoma, with damage to the optic nerve, visual field defects (in patients receiving prolonged ophthalmic corticosteroid therapy (more than 10 days), intraocular pressure should be checked routinely), and posterior subcapsular cataract formation. Topical corticosteroids may induce scleral or corneal perforation.Īllergic reaction, burning, transient blurring of vision, redness. Viral and fungal infections may be exacerbated by corticosteroids. ![]()
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